One Work


“In some respects, ketamine (and by extension, esketamine) represents a novel approach to treating depression, since it works differently from other approved drug treatments. But this is not because of the hallucinogenic experiences it prompts. Medical explanations for its efficacy against depression focus on its activity on neurotransmitters and receptors, and how it prompts the brain to generate new neural pathways. It has nothing to do with anything that occurs in one’s consciousness. The extremely specific and personal experiences of depression – the suicidal thoughts, the internal monologues of self-loathing, the cold scrutiny of the world’s pointed indifference – are likewise seen as epiphenomena, inessential chimeras to be dispersed through chemical rebalancing…”

– This text appears in Spike #59. You can buy it in our online shop –